A Case of Cicatricial Alopecia Associated with Erlotinib
نویسندگان
چکیده
Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia.
منابع مشابه
Descriptive study of primary Cicatricial Alopecia in patients referred to the Skin Clinic of Sina Hospital in Tabriz, 1997-2004
Background and aim: Cicatrical alopecia refers to lesions associated with permanent destruction of hair follicles. Several diseases such as folliculitis decalvans, lichenplanopilaris (LPP) and discoid lupus erythematosus (DLE) may result in cicatricial alopecia. Since cicatricial alopecia is scarring and affects both the appearance and psychosocial behaviours of the patients and also it c...
متن کاملفراوانی انـواع آلوپسـی‌های سیـکاتریسـیل اولیـه در بیمـاران یک درمانگاه پوست مرجع در همدان: مطالعه‌ای بالینی ـ آسیب‌شناختی
Background and Aim: Cicatricial alopecia refers to lesions that result in permanent and irreversible hair loss and are associated with destruction of hair follicles. In this alopecias the hair follicle is replaced with connective tissue. After remission of initial infection or inflammation, hair regrowth is unlikely. Methods: In this retrospective cross-sectional study, 222 patients with cic...
متن کاملویژگیهای دموگرافیک، بالینی و هیستوپاتولوژیک در انواع مختلف آلوپسی سیکاتریسیل
Background and Aim: Cicatricial alopecia is the result of irreversible substitution of hair follicles with fibrotic tissue and presents as permanent loss of hair. Only a few studies have investigated the clinical and histopathological characteristics of cicatricial alopecia in Iran. The aim of this study was to determine the demographic, clinical and histopathological characteris...
متن کاملKeratosis follicularis spinulosa decalvans: case report.
Keratosis follicularis spinulosa decalvans is a rare disease, with genetic transmission either X-linked or sporadic, characterized by follicular hyperkeratosis and cicatricial alopecia. The disease usually begins in early childhood exacerbating throughout adolescence. The therapies are somewhat effective, with frustrating treatment when there are changes which are predominantly cicatricial. It ...
متن کاملEvaluation of clinical-pathologic causes of scarring alopesia in patients referred to dermatology clinic of Imam Reza Hospital in Ardebil during the year of 2018
Background and Aim: Cicatricial (scarring) alopecia is a group of disorders in which permanent hair loss results from replacement of hair follicles by fibrosis or hyalinized collagen, which includes two types: primary such as discoid lupus erythematosus (DLE), lichen plano pilaris (LPP), frontal fibrosing alopecia (FFA), Folliculitis decalvans, and secondary like kerion and burn. The aim of thi...
متن کامل